{"id":46708,"date":"2020-08-17T18:11:52","date_gmt":"2020-08-17T18:11:52","guid":{"rendered":"https:\/\/lnbr.cnpem.br\/?page_id=46708"},"modified":"2021-09-29T19:47:50","modified_gmt":"2021-09-29T19:47:50","slug":"enzimologia-e-engenharia-de-proteinas","status":"publish","type":"page","link":"https:\/\/lnbr.cnpem.br\/divisoes-de-pesquisa\/biotecnologia-molecular\/enzimologia-e-engenharia-de-proteinas\/","title":{"rendered":"LNBR | Enzimologia e Engenharia de Prote\u00ednas"},"content":{"rendered":"

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Descoberta de enzimas, compreens\u00e3o mecan\u00edstica a n\u00edvel at\u00f4mico e projeto racional<\/span><\/strong><\/span><\/p>\n

As enzimas s\u00e3o componentes vitais na produ\u00e7\u00e3o de Biorrenov\u00e1veis, desde a despolimeriza\u00e7\u00e3o da biomassa at\u00e9 a convers\u00e3o em produtos de valor agregado e biocombust\u00edveis. Os coquet\u00e9is enzim\u00e1ticos s\u00e3o fundamentais para quebrar a lignocelulose em a\u00e7\u00facares avan\u00e7ados e lignina que ser\u00e3o fermentados por plataformas microbianas engenheiradas. Um not\u00e1vel esfor\u00e7o no desenvolvimento de linhagens industriais abrange caminhos metab\u00f3licos, que s\u00e3o essencialmente um conjunto de enzimas em s\u00e9rie, bioquimicamente correlacionadas, para gerar mol\u00e9culas altamente puras e complexas.<\/span><\/p>\n

O LNBR estabeleceu abordagens chave para a descoberta, compreens\u00e3o e redesenho de enzimas. A descoberta \u00e9 baseada em an\u00e1lises \u00f4micas incluindo gen\u00f4mica, transcript\u00f4mica, prote\u00f4mica e metabol\u00f4mica. Isto implica em uma compreens\u00e3o completa das propriedades funcionais e da divis\u00e3o estrutural, incluindo itiner\u00e1rios conformacionais das rea\u00e7\u00f5es catal\u00edticas e determinantes estruturais para o modo de clivagem e a especificidade do substrato. O redesenho depende muito da elucida\u00e7\u00e3o mecan\u00edstica que permite estrat\u00e9gias racionais e orientadas para a estrutura. Em \u00faltima an\u00e1lise, o LNBR visa criar novas fun\u00e7\u00f5es enzim\u00e1ticas que n\u00e3o est\u00e3o presentes na natureza para alavancar a gera\u00e7\u00e3o de novas classes de relev\u00e2ncia industrial.<\/span><\/p>\n

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\nBiotecnologia para Agricultura<\/a>
\nPlataformas Microbianas<\/a>
\nQu\u00edmica Sustent\u00e1vel<\/a>
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<\/div>[vc_accordion active_tab=”1″ collapsible=”yes” style=”2″][vc_accordion_tab title=”LIDERAN\u00c7A”][vc_column_text]Enzimologia & Engenharia de Prote\u00ednas
\n<\/strong>Leticia M. Zanphorlin
\nlnbr.dir@lnbr.cnpem.br<\/a><\/p>\n
\n
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[vc_row][vc_column width=”3\/4″][vc_row_inner][vc_column_inner][vc_column_text] Descoberta de enzimas, compreens\u00e3o mecan\u00edstica a n\u00edvel at\u00f4mico e projeto racional As enzimas s\u00e3o componentes vitais na produ\u00e7\u00e3o de Biorrenov\u00e1veis, desde a despolimeriza\u00e7\u00e3o da biomassa at\u00e9 a convers\u00e3o em produtos de valor agregado e biocombust\u00edveis. Os coquet\u00e9is enzim\u00e1ticos s\u00e3o fundamentais para quebrar a lignocelulose em a\u00e7\u00facares avan\u00e7ados e lignina que ser\u00e3o fermentados por…<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":46707,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-46708","page","type-page","status-publish","hentry","description-off"],"acf":[],"_links":{"self":[{"href":"https:\/\/lnbr.cnpem.br\/en\/wp-json\/wp\/v2\/pages\/46708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lnbr.cnpem.br\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lnbr.cnpem.br\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lnbr.cnpem.br\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/lnbr.cnpem.br\/en\/wp-json\/wp\/v2\/comments?post=46708"}],"version-history":[{"count":0,"href":"https:\/\/lnbr.cnpem.br\/en\/wp-json\/wp\/v2\/pages\/46708\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/lnbr.cnpem.br\/en\/wp-json\/wp\/v2\/pages\/46707"}],"wp:attachment":[{"href":"https:\/\/lnbr.cnpem.br\/en\/wp-json\/wp\/v2\/media?parent=46708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}